Platelet-Activating Factor Receptor Contributes to Antileishmanial Function of Miltefosine

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Platelet-activating factor receptor contributes to antileishmanial function of miltefosine.

Miltefosine [hexadecylphosphocholine (HPC)] is the only orally bioavailable drug for the disease visceral leishmaniasis, which is caused by the protozoan parasite Leishmania donovani. Although miltefosine has direct leishmanicidal effects, evidence is mounting for its immune system-dependent effects. The mechanism of such indirect antileishmanial effects of miltefosine remains to be discovered....

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2015

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.1401890